Kisii University Portal, the government of Kenya mandated the university to take over the college as its campus in 1994. Kisii Campus was one of the earliest campuses to be created in Kenya by the then Head of State, H.E. Daniel arap Moi. In 1999, the Faculty of Commerce established a Bachelor of Business and Management as its first degree programmes within the campus to run alongside a postgraduate Diploma in Education, which was phased out in 2001.
On 23 August 2007, Kisii University College was established through a Government Legal Notice No.163 of 2007 as a constituent college of Egerton University. On 6 February 2013, it was awarded a charter to become the 13th public university in Kenya. The university main campus is situated 2 km from Kisii Town Centre, off the Kisii – Kilgoris Road. Kisii University is a university located in Kisii. It was founded in 1965 as a primary teachers’ training college on a 61-acre land that was donated by the County Council of Gusii. The college continued up to 1983 when it was upgraded to a secondary teachers’ college to offer Diploma programmes.